Topic: James Downing

Gene Governs Response to Leukemia Chemotherapy

1/7/2009 Print E-mail A mutation in leukemia cells predicts which children with acute lymphoblastic leukemia are more likely to relapse.. Scientists have already identified a number of genetic mutations and deletions in genes (including the one that's the subject ...

Podcast Interview >

From the Science Podcast: an interview with Charles Mullighan and James Downing on the origins of relapsed acute lymphoblastic leukemia. Subscribe to the Science Podcast. The contents of this podcast interview represent the opinion of the author and may go beyond the ...

How Childhood Leukemia Fights Back

What makes a cancer come back? For them, the chance of survival drops dramatically, to about 30%, says James Downing, St. Jude's scientific director. Tomorrow in Science, Downing and colleagues report that 92% of leukemia cells from relapsed patients harbored changes ...